Extended Data Fig. 2: Enrichment analysis of the muscle transcriptome from KrasG12D/+; Lkb1f/f lung cancer and C26 colon carcinoma-induced cachexia mouse models. | Nature Metabolism

Extended Data Fig. 2: Enrichment analysis of the muscle transcriptome from KrasG12D/+; Lkb1f/f lung cancer and C26 colon carcinoma-induced cachexia mouse models.

From: Impaired cAMP–PKA–CREB1 signalling drives mitochondrial dysfunction in skeletal muscle during cancer cachexia

Extended Data Fig. 2: Enrichment analysis of the muscle transcriptome from KrasG12D/+; Lkb1f/f lung cancer and C26 colon carcinoma-induced cachexia mouse models.

a,b, Top 10 terms from enrichment analysis for GO Biological Process 2025 (EnrichR) (a) and for transcription factor loss-of-function (TF-LoF) (b) of genes downregulated in skeletal muscle of KrasG12D/+; Lkb1f/f (KL) mice and not in fasted mice. Data from published gene set from Goncalves et al.31. c, Top 10 terms from enrichment analysis for transcription factor loss-of-function (TF-LoF) (EnrichR) of genes downregulated in skeletal muscle of C26-bearing mice at 13 days from tumour injection (C26 13d) vs. control mice. d, Top 10 terms from enrichment analysis for GO Biological Process 2025 (EnrichR) of genes concomitantly downregulated in C26 13d vs. control and in Creb1 TF-LoF term.

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