Fig. 7: Locus-wide and gene-based association plots for SLC25A13.
From: Glycerol-3-phosphate activates ChREBP, FGF21 transcription and lipogenesis in citrin deficiency
a, Phenome-wide association study for rs80338722 within BioBank Japan identified an association with low body weight. The x axis represents phenotypes within Biobank Japan, whereas the y axis is the −log10(P value) for the association between rs80338722 and each trait. The dashed grey line represents the moderate significance threshold (P < 1 × 10−3). b, The aggregated rare variant gene-based burden tests between SLC25A13 and 189 complex traits from the Common Metabolic Disease Knowledge Portal identified phenotypic associations, including high urinary sodium excretion and elevated bilirubin. The traits above the orange dashed line (significance threshold P < 5 × 10−2) are statistically significant. Tiangles pointing up indicate associations with increased trait levels or disease risk, whereas the triangles pointing down indicate associations with decreased traits levels or disease risk. c, Common variant gene-based tests for SLC25A13 and 189 complex traits from the Common Metabolic Disease Knowledge Portal identified a strong association with oily fish consumption. Traits above the orange dashed line (threshold P < 2.5 × 10−6) are nominally significant. ApoA, apolipoprotein A; ApoB, apolipoprotein B; BMI, body mass index; adj, adjusted; HDL, high density lipoprotein; ASCVD, atherosclerotic cardiovascular disease; NAFLD, nonalcoholic fatty liver disease; HOMA-IR, homeostatic model assessment of insulin resistance; CCS, coronary calcium score.
