Extended Data Fig. 3: Chronic changes in the plasma NAD+ metabolome after precursor supplementation.
Raw plasma concentrations of NAD+ derived metabolites (yellow) and NAD+precursors (blue) before and after supplementation with placebo, Nam, NR or NMN for 2 weeks. Data are shown for MeNam (a), MeXPY (b), NR (c), NMN (d) and NAM (e). Boxes ranging from the upper to the lower quartile with an indication of the median and the error bars represent the minimal and maximal values. The number of data points is indicated below each treatment. Statistical significance of the differential changes compared to placebo is indicated (based on two-sided ANCOVA). * (0.05<P < 0.01), ** (0.01<P < 0.001), *** (P < 0.001). # indicates that no statistical analysis was performed as only ~25 % of the concentrations were above LLOQ (0.01 µM).
