Extended Data Fig. 10: Nerves from Rxfp1+ sympathetic neurons are closely associated with blood vessels in mouse iBAT.
From: Distinct sympathetic projections to brown fat regulate thermogenesis and glucose tolerance
a, Diameter of iBAT blood vessels innervated by tdTomato-positive nerves in Rxfp1-Cre::tdTomato mice (2 mice, 3 regions analyzed per mouse, n = 24 unique innervated blood vessels from one mouse and n = 47 from the other). Data presented as box plots. Whiskers indicate min and max values, left and right borders are 25th and 75th percentile, center is the median. b, Proportion of distances between tdTomato-positive nerves and their closest blood vessel in iBAT of Rxfp1-Cre::tdTomato and Th-Cre::tdTomato mice, grouped into 1 µm bins (2 mice per genotype, 3 regions analyzed per mouse, P < 0.001). c, Same data from b, grouped in bins of either 0, 0.41-2, 2-15 or >15 µm, P < 0.001. b, Chi-squared test, two-tailed, P < 0.001. c, Kolmogorov-Smirnov test, two-sided, P < 0.001.
