Extended Data Fig. 6: Loss of hepatic Gpr110 has no obvious effects on serum lipid and glucose levels or glucose metabolism in male or female mice.
10-week-old male and female LKO mice and their WT littermates were fed with STC or choline-deficient high-fat (CDHF45) diet for 32 weeks. a,b,d,e, Serum levels of TG and FFA in male (a,b) and female (d,e) mice. c,f, Blood glucose levels at fed and fasting states in male (c) and female (f) mice. g-l, Serum levels of TC, HDL and LDL in male (g,h,i) and female (j,k,l) mice. m,n, Glucose tolerance test (GTT) performed at the 30th week of study and the area under curve (AUC) during GTT in male (m) and female (n) mice. o,p, Insulin tolerance test (ITT) performed at the last week of study and AUC during ITT in male (o) and female (p) mice. n = 5/group for male and female WT and LKO mice on STC, n = 6/group for male and female WT and LKO mice on CDHF45. Data are presented as mean ± SD; Statistical significance was calculated using one-way ANOVA followed by Tukey’s multiple comparisons test (a-l,m-p right panels) or two-way ANOVA followed by Tukey’s multiple comparisons test (m-p left panels).
