Extended Data Fig. 6: Diagram summarizing metabolic rewiring in clear cell renal cell carcinoma (ccRCC) cells expressing CrGPDH.
From: A genetically encoded bifunctional enzyme mitigates redox imbalance and lipotoxicity
(a) In ccRCC cells, the Gro3P shuttle is functionally truncated, as cytosolic cGPDH is uncoupled from mitochondrial mGPDH, thereby supporting a robust Gro3P pool for TG synthesis57. (b) Expression of CrGPDH in these cells facilitates efficient Gro3P clearance, leading to suppression of TG synthesis. FFA: free fatty acid; TG: triglycerides; GL/FFA cycle: glycerolipid/free fatty acid cycle; GK: glycerol kinase.
