Extended Data Fig. 9: Hepatic lipid profiles of CrGPDH expression in mice.
From: A genetically encoded bifunctional enzyme mitigates redox imbalance and lipotoxicity
Volcano plots of summed lipid classes. Comparisons are: (a) CrGPDH versus GFP under water gavage, (b) ethanol versus water in GFP-expressing mice, and (c) CrGPDH versus GFP under ethanol gavage. (d) Heatmaps of all detected lipids, clustered by each lipid class across the indicated groups. Significantly increased summed lipids (log2FC > 0.1, p < 0.05) are shown in red, decreased summed lipids (log2FC < -0.1, p < 0.05) in dark blue, and nonsignificant ones in gray. ChE: Cholesterol ester, CoQ: Coenzyme Q-like molecules, DG: Diglycerides, HexCer: Ceramide with hexose, LBPA: Glycerophosphoglycerols, LPC: Lysophosphatidylcholine, LPE: Lysophosphatidylethanolamine, LPI: Lysophosphatidylinositol, MePC: Methyl phosphatidylcholine, PA: Phosphatidic acid, PC: Phosphatidylcholine, PE: Phosphatidylethanolamine, PG: Phosphatidylglycerol, PI: Phosphatidylinositol, PS: Phosphatidylserine, SM: Sphingomyelin, TG: triglycerides. In heatmaps in (d), each column represents a biologically independent sample.
