Extended Data Fig. 10: Anti-lipid peroxidation interventions preserve NE morphology and delay cell senescence in normal and HGPS cells. | Nature Metabolism

Extended Data Fig. 10: Anti-lipid peroxidation interventions preserve NE morphology and delay cell senescence in normal and HGPS cells.

From: Mitochondrial superoxide regulates nuclear envelope integrity and ageing via redox-mediated lipid metabolism

Extended Data Fig. 10: Anti-lipid peroxidation interventions preserve NE morphology and delay cell senescence in normal and HGPS cells.

a-c, Analysis workflow of the roundness (a), smoothness (b), and invagination of nuclear envelope (c) of the nuclei in BJ fibroblasts. d-f, Quantification of the roundness (d), smoothness (e), and invagination (f) of the nuclei in BJ fibroblasts. 20 nuclei were analyzed in (b). 50 nuclei were examined for each group (d); Scale bars, 10 μm (a,b,c). Data are mean ± s.e.m. P values were calculated using One-way ANOVA (d,e,f). Source numerical data are available in the source data.

Source data

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