Extended Data Fig. 6: Additional tanycyte profiling in female Rab27a KD model. | Nature Metabolism

Extended Data Fig. 6: Additional tanycyte profiling in female Rab27a KD model.

From: Metabolic regulation by tanycyte-derived extracellular vesicles through insulin precursor-mediated neuronal recognition and mTORC component delivery

Extended Data Fig. 6: Additional tanycyte profiling in female Rab27a KD model.

Mediobasal hypothalamus containing tanycytes along the 3V from Rab27a KD and control (Con) were sectioned and immunostained for additional evaluations including tanycyte morphology through Nestin immunostaining (a), apoptotic biomarker through immunostaining of cleaved caspase 3 (b), and transcytosis of Alexa 594-labelled leptin (2 mg/kg body weight) following a systemic administration through an intraperitoneal injection (c). DAPI staining (blue) was merged to show the background of sections. Scale bar, 100 μm.

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