Extended Data Fig. 4: Other pathways of interest identified from RNAseq & Metabolomics.
From: NADPH-producing enzymes restrict the formation of pancreatic precancerous lesions
a. Heatmap of the leading edge genes in the Purine Metabolism KEGG pathway. Scale represents log2FC relative to Vehicle. b. Violin plot of the 40 leading edge genes in the Purine Metabolism KEGG pathway. Y-axis represents log2FC relative to Vehicle. c. Violin plot of the 93 detected genes in the Purine Metabolism KEGG pathway. Y-axis represents log2FC relative to Vehicle. d. Heatmap of detected purine-related metabolites. Scale represents log2FC of median normalized abundance relative to Vehicle. e. Heatmap of detected pyrimidine-related metabolites. Scale represents log2FC of median normalized abundance relative to Vehicle. f. Heatmap of genes that encode core enzymes in pyrimidine metabolism. Scale represents log2FC relative to Vehicle. g. Violin plot of the 38 detected genes in the Fatty Acid Degradation KEGG pathway. Y-axis represents log2FC relative to Vehicle. h. Heatmap of detected amino acid abundances. Scale represents log2FC of median normalized abundance relative to Vehicle. i. Heatmap of genes that encode core enzymes in branched-chain amino acid (BCAA) metabolism. Scale represents log2FC relative to Vehicle.
