Extended Data Fig. 3: Physical activity and cognitive ability in centenarians as predictors of survival and their association with plasma NfL.
From: A neuronal blood marker is associated with mortality in old age
a, b, Kaplan-Meier survival curve for Activity of Daily Living (ADL: no (n = 38), moderate (n = 53), severe disability(n = 44)) and Mini-Mental State Estimation (MMSE: 0–17 (n = 37), 18–23 (n = 45), 24–30 (n = 46)). For Cox regression analysis see Table 2. c, d, Plasma NfL concentrations (Box plots showing center line as the median, the box as the first and third quartile and the whiskers as the adjacent values which are the largest observation that is less or equal than the third quartile + 1.5 x interquartile range and the lowest observation that is greater or equal than the first quartile - 1.5 x interquartile range) for the different ADL and MMSE categories. The association between NfL and ADL across all three groups was not significant with an estimated median increase of NfL of 3.7 pg/ml with increasing disability (95% CI: (−4.2; 11.7), p = 0.354). In contrast, the association between NfL and MMSE was significant across all three groups with an estimated median decrease of NfL of 8.5pg/ml with increasing MMSE (95% CI: (2.3; 14.7), p = 0.008).
