Extended Data Fig. 4: Survival prediction for NfL, MMSE, and ADL disability.
From: A neuronal blood marker is associated with mortality in old age
The size of the prediction was estimated as area under the curve (AUC) from the prediction of survival from blood sample until a certain age (the x-axis of time-dependent AUC). a, Survival prediction for the centenarians up to 103 years of age. The average AUC over the follow-up period were for the centenarians 0.65, 95% CI: (0.56: 0.75), 0.62, 95% CI: (0.52: 0.72) and 0.64, 95% CI: (0.54: 0.73) for NfL, MMSE and ADL, respectively. b, Survival prediction for the 93-year-old nonagenarians up to 100 years of age. The average AUC over the follow-up period were for the nonagenarians 0.68, 95% CI: (0.59: 0.76), 0.55, 95% CI: (0.46: 0.64) and 0.63, 95% CI: (0.54: 0.71) for NfL, MMSE and ADL, respectively. These observations indicate that blood NfL predicts survival better compared to MMSE and ADL.
