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TISSUE REGENERATION

Anti-aging therapy for pulmonary fibrosis

Nature Aging volume 1, pages 155–156 (2021)Cite this article

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Accelerated aging and cellular senescence are driving forces of pulmonary fibrosis. A novel anti-aging therapeutic approach combats lung fibrosis by targeting senescent fibrogenic cells for apoptosis.

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Fig. 1: Anti-aging therapy for pulmonary fibrosis.

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Acknowledgements

D.L. gratefully acknowledges funding support from the NIH (grant R01 HL147059-01), the start-up package from Massachusetts General Hospital and sponsored research grants from Boehringer Ingelheim.

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Authors and Affiliations

  1. Department of Medicine, Division of Pulmonary and Critical Care Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA

    Yan Zhou & David Lagares

  2. Fibrosis Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA

    Yan Zhou & David Lagares

  3. Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, USA

    Yan Zhou & David Lagares

  4. Department of Physiology, Xiangya Medical School, Central South University, Hunan, China

    Yan Zhou

Authors
  1. Yan Zhou
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  2. David Lagares
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Correspondence to David Lagares.

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Competing interests

D.L. declares that he has received research funding from Boehringer Ingelheim, Indalo Therapeutics, Merck and Unity Biotechnology. D.L. has a financial interest in Mediar Therapeutics and Zenon Biotech. The companies are developing treatments for organ fibrosis. D.L.’s interests were reviewed and are managed by MGH and Partners HealthCare in accordance with their conflict of interest policies.

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Zhou, Y., Lagares, D. Anti-aging therapy for pulmonary fibrosis. Nat Aging 1, 155–156 (2021). https://doi.org/10.1038/s43587-021-00035-5

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