Extended Data Fig. 1: Disease categories and co-occurrences.
From: Common genetic associations between age-related diseases
a, Disease hierarchy for the 116 diseases included in the analysis. The nodes are colored by the disease categories as indicated in the legend. b, Disease co-occurrence matrix summarizing relative risk scores and correlations. Each row and column denote diseases ordered by hierarchical clustering of risk scores. The color is defined by relative risk scores while the size is determined by ϕ value, indicating the robustness of the association (see Methods). The diagonal tiles are colored by the UK Biobank’s disease hierarchy to visualize if diseases from the same category cluster together. Associations for the 62 diseases that have at least one relative risk ratio higher than four (log2RR ≥ 2) or lower than minus four log2RR ≤ −2 are plotted.
