Extended Data Fig. 10: Clinical landscape of human KDM4 in cancer genomics.

a, OncoPrint view of human KDM4 alterations. Multidimensional cancer genomics datasets of KDM4 mutations in human prostate cancer (PCa) patients were mapped. Data from 3317 patients (3480 biospecimens) out of 10 individual clinical studies were subject to analysis and visualization, with source data from the Cancer Genome Atlas (TCGA), a landmark cancer genomics program. Top columns, individual patients affected by particular alterations. b, OncoPrint view of similar genomics mapping presentation of human KDM4 alterations in breast cancer (BCa) patients. Data from 4559 patients (4625 biospecimens) out of 10 individual clinical studies were incorporated. Source data derived from the TCGA portal. c, Cancer type-specific summary of human KDM4 mutations in PCa patients. Data were pooled from 8 separate studies that reported single-site mutations, amplifications, deep deletions and multiple alterations of human KDM4. d, Cancer type-specific summary of human KDM4 mutations in BCa patients. Data were pooled from 10 separate studies that reported single-site mutations, fusions, amplifications, deep deletions and multiple alterations of human KDM4.