Extended Data Fig. 5: Functional profiling of protein Network 2 and Network 3 identified among the set of dementia-associated proteins.
From: Large-scale plasma proteomic analysis identifies proteins and pathways associated with dementia risk
Protein networks were assembled based on evidence of known gene/molecule interactions in the Ingenuity Knowledge Base. The g:Profiler toolkit106 was used to analyze the proteins in each dementia-associated protein network for functional enrichment. We defined the biological pathways/processes associated with each protein set using the Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG), and WikiPathways databases. Images were generated using the g:Profiler web tool: https://biit.cs.ut.ee/gprofiler/. Abbreviations: GO:BP, gene ontology biological process; GO:MF, gene ontology molecular function.
