Extended Data Fig. 2: Additional characterization of cerebral blood flow reductions in old APOE4 and APOE4;5xFAD male and female mice. | Nature Aging

Extended Data Fig. 2: Additional characterization of cerebral blood flow reductions in old APOE4 and APOE4;5xFAD male and female mice.

From: APOE4 accelerates advanced-stage vascular and neurodegenerative disorder in old Alzheimer’s mice via cyclophilin A independently of amyloid-β

Extended Data Fig. 2: Additional characterization of cerebral blood flow reductions in old APOE4 and APOE4;5xFAD male and female mice.The alternative text for this image may have been generated using AI.

Cerebral blood flow (CBF) values in the cortex (Ctx) and hippocampus (Hipp) in male and female E3 (n = 12, 6 ♂ and 6 ♀; blue empty circles), E4 (n = 14, 7 ♂ and 7 ♀; blue filled circles), E3+FAD (n = 13, 8 ♂ and 5 ♀; red empty circles), and E4+FAD (n = 16, 11 ♂ and 5 ♀; red filled circles) mice generated from dynamic susceptibility-contrast magnetic resonance scans. Mice (both genders) were 18–24-month old. Data are presented as truncated violin plots; continuous line, median; dotted line, interquartile range. Significance by one-way ANOVA followed by the Tukey post hoc test; ns, non-significant.

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