Extended Data Fig. 2: Additional characterization of cerebral blood flow reductions in old APOE4 and APOE4;5xFAD male and female mice. | Nature Aging

Extended Data Fig. 2: Additional characterization of cerebral blood flow reductions in old APOE4 and APOE4;5xFAD male and female mice.

From: APOE4 accelerates advanced-stage vascular and neurodegenerative disorder in old Alzheimer’s mice via cyclophilin A independently of amyloid-β

Extended Data Fig. 2

Cerebral blood flow (CBF) values in the cortex (Ctx) and hippocampus (Hipp) in male and female E3 (n = 12, 6 ♂ and 6 ♀; blue empty circles), E4 (n = 14, 7 ♂ and 7 ♀; blue filled circles), E3+FAD (n = 13, 8 ♂ and 5 ♀; red empty circles), and E4+FAD (n = 16, 11 ♂ and 5 ♀; red filled circles) mice generated from dynamic susceptibility-contrast magnetic resonance scans. Mice (both genders) were 18–24-month old. Data are presented as truncated violin plots; continuous line, median; dotted line, interquartile range. Significance by one-way ANOVA followed by the Tukey post hoc test; ns, non-significant.

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