Extended Data Fig. 8: Human blood endothelial progenitor cells and mice endothelial cells. | Nature Aging

Extended Data Fig. 8: Human blood endothelial progenitor cells and mice endothelial cells.

From: An inflammatory aging clock (iAge) based on deep learning tracks multimorbidity, immunosenescence, frailty and cardiovascular aging

Extended Data Fig. 8: Human blood endothelial progenitor cells and mice endothelial cells.The alternative text for this image may have been generated using AI.

a, Representative images of human blood progenitor endothelial cells from young (left) and old (right) individuals. b, Representative images of capillary-like networks show impaired tube formation by human BECs of old individuals compared to young. To further confirm the potential contribution of CXCL9 in cardiovascular aging, we assessed its expression in young (3–4 month) and old mice (2 yr.) endothelial cells (c). ECs isolated from old mice showed higher levels of CXCL9 (P value = 0.023) (d), while at the same time showed impaired EC function as evident by decreased tube formation (P value = 0.042) (a, f). Figure S8: All data represented as mean ± SEM, n = 3, *P < 0.05. Statistical analyses were performed using Student’s t-test (paired). Scale bar: 50 μm.

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