Extended Data Fig. 1: ABT263 depletes SNCs and reduces foam cell macrophage content in intermediate-stage lesions.
From: Senescent cells suppress innate smooth muscle cell repair functions in atherosclerosis
a, Representative SA β-Gal+ cells in H-E stained aortic arch plaques from indicated groups and quantified in b (left). b, (Left) Quantification of SA β-Gal+ cell counts in mice from indicated groups. (Right) En face quantification of SA β-Gal+ lesional surface area in mice from indicated groups. c, Representative foam cell macrophage pockets (black traced areas; quantified in d) in mice from 12-week HFD-fed Ldlr –/– mice and 12-week HFD-fed Ldlr –/– switched to LFD for 9 weeks with either 3x ABT263 or 3x Veh administration. d, Quantification of foam cell macrophage content per section (legend as in b). ‘n’ refers in all panels to number of mice. Statistics in panel b (left) and d were performed by ordinary one-way ANOVA with Holm-Sidak multiple comparison correction for the indicated comparisons. Panel b (right) was analyzed by unpaired, two-tailed t-test with Welch’s correction. Error bars represent s.e.m. Scale bars are 50 µm (a) and 100 µm (c).
