Fig. 5: Transcriptomes of HR MEps resemble aged MEps and map to inflammatory and cancer-related pathways. | Nature Aging

Fig. 5: Transcriptomes of HR MEps resemble aged MEps and map to inflammatory and cancer-related pathways.

From: Evidence for accelerated aging in mammary epithelia of women carrying germline BRCA1 or BRCA2 mutations

Fig. 5

a, Volcano plot of DE genes in HR compared with AR MEps. b, MSigDB hallmark gene sets enriched in HR MEps compared with AR MEps. c, KEGG pathways overrepresented in HR MEps compared with AR MEps. The size of the circles reflects the number of genes per pathway. d, Venn diagram of DE genes of three comparisons: HR versus AR younger (≤35 years) MEps, HR versus AR older (>55 years) MEps and AR older versus AR younger MEps. e, A matrix of genes overlapping across several comparisons. Numbers in the matrix represent P values whereas the color gradient is the log2(OR) of the overlap. The P values were computed using Fischer’s exact test within the GeneOverlap package for each pair of gene lists compared in a one-sided manner (alternative = greater). M.HR.v.AR, genes upregulated in HR MEps compared with AR MEps; M.HR.v.AR.Y, genes upregulated in HR MEps compared with AR younger MEps (≤35 years); M.BRCA1.v.Non.RM, genes upregulated in MEps harboring BRCA1 mutations compared with AR MEps that do not harbor any mutations collected from reduction mammoplasties.

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