Extended Data Fig. 10: The most down-regulated and up-regulated gene groups in spinal cords of neuronal ARF1-KO mice. | Nature Aging

Extended Data Fig. 10: The most down-regulated and up-regulated gene groups in spinal cords of neuronal ARF1-KO mice.

From: Neuronal accumulation of peroxidated lipids promotes demyelination and neurodegeneration through the activation of the microglial NLRP3 inflammasome

Extended Data Fig. 10

a-d, The most down-regulated and up-regulated genes related to myelin and inflammatory responses are shown in neuronal ARF1-KO in comparison with control mice. Myelin sheath genes (a) and inflammatory response genes (c) were shown in spinal cord of neuronal ARF1-KO mice. The networks of Myelin sheath genes (b) and the inflammatory genes (d) through analyzing protein-protein interaction (PPI) using WebGestalt online software. e, Proposed model of ARF1-ablation-induced neurodegeneration.

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