Extended Data Fig. 6: Systemic inhibition of Stat3 activation limits OA lesions caused by K2 loss.
From: Kindlin-2 preserves integrity of the articular cartilage to protect against osteoarthritis
(a) A schematic diagram illustrating the experimental design. (b) Stattic improves restriction of movement of knee joint caused by K2 loss in DMM mice. (c) SO&FG (left panels), IF (middle panels) and H&E (right panels) staining of knee joint sections from cKO mice treated with PBS or Stattic for 2 months after DMM surgery. Scale bar, 50 μm. (d-g) OARSI score (d), cartilage area (e), osteophyte score (f) and synovitis score (g) were analyzed using histological sections. For all experiments, n = 8 biologically independent animals per group and results from one representative replicate are shown in b, c. Quantitative data are shown as mean ± standard deviation in d-g. The exact p values are shown in figures. Two-sided unpaired t-test was used for statistical analysis.
