Extended Data Fig. 9: Effect of Runx2 haploinsufficiency in chondrocytes on cartilage loss caused by K2 loss.
From: Kindlin-2 preserves integrity of the articular cartilage to protect against osteoarthritis
(a) A schematic diagram illustrating the experimental design. (b) Alcian blue & orange G-stained sections of knee joints of K2fl/fl; AggrecanCreERT2 mice and K2fl/fl; Runx2fl/+; AggrecanCreERT2 mice subjected to sham or DMM surgeries and tamoxifen injections as described in (a). Scale bar: 50 μm. (c) Quantification of cartilage loss. n = 6 biologically independent animals per group and results from one representative replicate are shown in b. Quantitative data are shown as mean ± standard deviation in c. The exact p values are shown in figures. Two-sided unpaired t-test was used for statistical analysis.
