Extended Data Fig. 10: Effect of Stat3/Runx2 double haploinsufficiency in chondrocytes on DMM-induced OA lesions.
From: Kindlin-2 preserves integrity of the articular cartilage to protect against osteoarthritis
(a) A schematic diagram illustrating the experimental design. (b) SO&FG-stained sections of the knee joints of Stat3fl/+; AggrecanCreERT2, Runx2fl/+; AggrecanCreERT2 and Stat3fl/+; Runx2fl/+; AggrecanCreERT2 mice subjected to DMM/sham surgery and tamoxifen (TAM)/corn oil injections as described in (a). Scale bar: 50 μm. (c) OARSI score. (d) Loss of cartilage. For all experiments, n = 6 biologically independent animals per group and results from one representative replicate are shown in b. Quantitative data are shown as mean ± standard deviation in c, d. The exact p values are shown in figures. Two-sided unpaired t-test was used for statistical analysis.
