Extended Data Fig. 6: Analyses of plasma metabolome.
a, Spearman association analysis between MetaCyc pathways of gut microbiome and plasma metabolites. Rows show MetaCyc pathways and columns show plasma metabolites. Asterisks denote spearman correlation test results (*FDR < 5 × 10-4, **FDR < 1 × 10-4). b, Associations between plasma levels of dehydroepiandrosterone sulfate (DHEA-S; its decline in elderly people is linked to Alzheimer’s disease) or biochemically related epiandrosterone sulfate and microbiome pathways. c, Analysis of two inflammatory cytokines in the Qidong validation cohort (33 pairs of nonagenarians (N=33) and their offspring (N=33)). The boxes represent the interquartile range (IQR), from the first and third quartiles, and the inside line represents the median. The whiskers denote the lowest and highest values within 1.5 IQR from the first and third quartiles. The circles represent outliers beyond the whiskers.
