Extended Data Fig. 7: Analysis of quantitative trait loci (QTL) of plasma metabolites.
Genomic regions accommodating a cluster of associations with a circulating metabolite that are shared by the two generations (a) or found only in the offspring (b). The associations between 3-aminoisobutarate and 5p13.2 were largely offspring-specific, although there were 3 pairs of cross-generational QTLs. FDR value and fold change of the relevant metabolite are marked at the upper left of each box plot (top row or single row, primary Qidong cohort; bottom row; validation Qidong cohort).
