Extended Data Fig. 9: Longitudinal nature of the brain age gap in ADNI cohort.
From: Deep learning-based brain age prediction in normal aging and dementia
a, Baseline brain age gap comparison between groups for FDG model. A statistical test was performed within the same baseline groups using a two-sided two-sample Student's t-test. b, For FDG model, the annual Δ brain age gap of each group was compared with the CU to CU group using one-way ANOVA with Holm-Sidak post hoc. c, Baseline brain age gap comparison between groups for MRI model. A statistical test was performed within the same baseline groups using a two-sided two-sample Student's t-test. d, For MRI model, the annual Δ brain age gap of each group was compared with the CU to CU group using one-way ANOVA with Holm-Sidak post hoc test). * p < 0.05, **p < 0.005, *** p < 0.001. n = 124, 20, 237, 46, and 28 for CU to CU, CU to MCI/AD, MCI to MCI, MCI to AD, and AD to AD group, respectively. Box plots represent the minimum and maximum values (whiskers), the first and third quartile (box boundaries), and the median (internal line).
