Extended Data Fig. 4: Heritability enrichment analyses in differentially abundant proteins identified in P301S and P301S;C1qKO synapse fractions. | Nature Aging

Extended Data Fig. 4: Heritability enrichment analyses in differentially abundant proteins identified in P301S and P301S;C1qKO synapse fractions.

From: Complement C1q-dependent excitatory and inhibitory synapse elimination by astrocytes and microglia in Alzheimer’s disease mouse models

Extended Data Fig. 4

(a) Manhattan plots of per-SNP enrichment p-values for the top 1000 down-regulated proteins in 9-month P301S and P301S;C1qKO PSDs for 752 traits across 23 of the 24 UK Biobank Domains. The dotted red line corresponds to the Bonferroni threshold at 0.05 correcting for 752 traits (6.65 ×10−5). (b) Per-SNP heritability coefficients and 95% confidence intervals of seven select cognitive and psychiatric traits for the top 1000 up- or down-regulated proteins in C1qKO, P301S and P301S;C1qKO PSDs at 6 and 9 months. The GWAS for the seven cognitive and psychiatric traits have sample sizes between 46,350 to 1.1 million individuals (see methods). Dots with p-value < 0.001 were labeled in the graph. All P values are one-sided and calculated using s-LDSC.

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