Extended Data Fig. 3: Proteomics analysis of insoluble fraction in WT and N40K-Tg mice. | Nature Aging

Extended Data Fig. 3: Proteomics analysis of insoluble fraction in WT and N40K-Tg mice.

From: Alzheimer’s disease-associated U1 snRNP splicing dysfunction causes neuronal hyperexcitability and cognitive impairment

Extended Data Fig. 3: Proteomics analysis of insoluble fraction in WT and N40K-Tg mice.

a, Proteomic profiling of detergent-insoluble proteome of WT and N40K-Tg mice (12-month-old, WT n = 3, Tg n = 3). b, Principal component analysis of the insoluble proteome of WT and N40K. c, Heatmap of differentially expressed proteins in N40K-Tg insoluble fraction. d, Pathway enrichment analysis of differentially expressed proteins in N40K-Tg insoluble fraction (Fisher’s exact test) followed by FDR analysis by the BH procedure. e, Enriched PPI module of spliceosomal snRNP complex (Fisher’s exact test and the BH procedure, FDR < 0.05). Each dot represents a protein, whereas the interactions are indicated by connected lines.

Back to article page