Extended Data Fig. 4: Distribution of the vaccine-induced S-specific CD4 + T cells among differentiation phenotypes.
From: Signs of immunosenescence correlate with poor outcome of mRNA COVID-19 vaccination in older adults
Distribution of the vaccine-induced S-specific CD4 + T cells among differentiation phenotypes. Distribution of the vaccine-induced S-specific CD4 + T cells among central memory (CM), effector memory (EM) and effector memory CD45RA + (EMRA) phenotype (22–40 yr, n = 21; 41–65 yr, n = 21; ≥ 66 yr, n = 12). S-specific response is determined based on cytokines production on non-naïve CD4 + T cells. Each dot represents a single study subject and horizontal lines indicate medians. P values were determined by two-tailed Kruskal-Wallis test with Dunn’s multiple comparison correction (3 age groups comparison); ** P < 0.01; ns: not significant.
