Extended Data Fig. 2: Gradient boosting regression prediction provides good accuracy even when no genes are detected as significantly differentially expressed, related to Fig. 1.
From: Aging is associated with a systemic length-associated transcriptome imbalance
(a) Number of differentially expressed genes relative to 4-month-old tissues detected at a false discovery rate of 0.05. Values shown are log10 (detected differentially expressed genes + 1). For example, a value of 1 in the figure indicates that 9 genes were detected to be differentially expressed. (b) Relationship between performance of the prediction accuracy (ρGBR) and the number of individual genes detected as differentially expressed at a false discovery rate of 0.05 across all tissue-age pairs. Reassuringly, we find a positive correlation between the two measures indicating that the ability to predict relative fold-changes is related to there being more genes differentially expressed. Shaded grey area indicates tissue-age pairs without any gene that is being detected as differentially expressed. (c) As panel b, but showing the significance of correlation between number of differentially expressed genes and the prediction accuracies instead of the prediction accuracy (ρGBR). Significance is determined using t-distribution for two-sided significance test for Spearman correlation66.
