Extended Data Fig. 3: Length-related features contain highly similar information toward age-dependent changes of the mouse transcriptome, related to Fig. 1.
From: Aging is associated with a systemic length-associated transcriptome imbalance
(a) Pairwise Spearman correlation between selected features. (b) Prediction accuracy of relative fold-change for samples from tissues of 24-month-old animals after excluding, in turn, gene length, transcript length, coding sequence (CDS) length, or no feature. The similarity of results confirms that all three length-related features provide the same level of information. (c) Importance of individual features or of the best-ranked feature within one group of related features in the gradient boosting regression models across n=17 tissues from 9-months-old mice. In boxplots center is median, notches bootstrapped 95% confidence interval of median, bounds of box 25% and 75% percentiles, whiskers extend height of box 1.5 times, minima and maxima observed minima and maxima.
