Fig. 4: Spike-specific antibody binding to Wuhan spike protein correlates with variant neutralization. | Nature Aging

Fig. 4: Spike-specific antibody binding to Wuhan spike protein correlates with variant neutralization.

From: Strong peak immunogenicity but rapid antibody waning following third vaccine dose in older residents of care homes

Fig. 4: Spike-specific antibody binding to Wuhan spike protein correlates with variant neutralization.

a, Wuhan spike-specific antibody titers in relation to variant of concern (VOC) neutralization. Blue dots and line indicate Delta neutralization (two-tailed Spearman’s correlation r = 0.80, P < 0.0001, n = 133) and green dots and line indicate Omicron neutralization (two-tailed Spearman’s correlation r = 0.82, P < 0.0001, n = 133). All fitted lines are linear regressions. b, Delta spike-specific antibody titer in relation to VOC neutralization. Blue dots and line indicate Delta neutralization (two-tailed Spearman’s correlation r = 0.81, P < 0.0001, n = 133) and green dots and line indicate Omicron neutralization (two-tailed Spearman’s correlation r = 0.81, P < 0.0001, n = 133). All fitted lines are linear regressions. c, Omicron spike-specific antibody titer in relation to VOC neutralization. Blue dots and line indicate delta neutralization (two-tailed Spearman’s correlation r = 0.76, P < 0.0001, n = 133) and green dots and line indicate omicron neutralization (two-tailed Spearman’s correlation r = 0.80, P < 0.0001, n = 133). All fitted lines are linear regressions.

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