Extended Data Fig. 4: Comparison of genes in cell-type-specific aging clocks and differentially expressed genes with age.

a, Volcano plots of negative log10 false discovery rate (FDR) from differential gene expression analysis using MAST for the young and old mouse groups. We defined ‘young’ as mice <7 months old and ‘old’ as mice >20 months old. Colored dots correspond to genes that contribute to the chronological aging clocks for each cell type (selected by clock) (orange representing genes with positive clock coefficients and blue representing genes with negative clock coefficients) and gray dots correspond to that do not contribute to the chronological aging clocks (not selected by clock). b, As in (a) but for the biological aging clocks.