Extended Data Fig. 5: Comparison of spike-specific CD4⁺ T cells between male and female, and CMV-seronegative and seropositive.

Frequency of AIM⁺ and cytokine⁺ CD4⁺ T cells from male (n = 99) and female (n = 117) donors (a) and CMV-seronegative and -seropositive donors aged 20–40 years (n = 29 and n = 54, respectively) (b, upper,) and in older adults (n = 9 and n = 100, respectively) (b, lower). The centerline and error bars indicate the median and IQR. The dotted line indicates limit of detection (LOD). Statistical comparisons across cohorts were performed using the Mann-Whitney U test. ns, not significant.

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