Extended Data Fig. 2: Effect of PI3K inhibitor (PI3Ki) on glucose homeostasis and insulin signalling with aging. | Nature Aging

Extended Data Fig. 2: Effect of PI3K inhibitor (PI3Ki) on glucose homeostasis and insulin signalling with aging.

From: Dietary supplementation of clinically utilized PI3K p110α inhibitor extends the lifespan of male and female mice

Extended Data Fig. 2

a, Plasma IGF1 at 20 months. b, Glucose tolerance test at 30 months of age. c, Plasma Fructosamine at 20 months. d, Blood glucose response to 3 hours of ad libitum access to food (chow diet) following an overnight fast at 20 months. Results are mean ± SE with biological replicates (individual mice, n) shown as individual data points or stated within figure. Significance was determined by two-way ANOVA (a-d) or RM two-way ANOVA (b, d) with Sidak post-hoc analysis for within sex effects when a significant sex x treatment interaction was seen. P-values within figures for PI3Ki vs vehicle of the same sex.

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