Fig. 4: Neuronal APOE4 removal ameliorates neuronal hyperexcitability in the hippocampus.
From: Neuronal APOE4 removal protects against tau-mediated gliosis, neurodegeneration and myelin deficits
a, Average normalized fPSP slopes in CA1 stratum radiatum in response to incremental stimulation of Schaffer collaterals. APOE4 expression renders CA3-CA1 network hyperexcitable as evidenced by augmented response to synaptic stimulation. b, Calculated individual field post-synaptic potentials (fPSP) slope gain values for all experiments in a. Note that removal of APOE4 from neurons ameliorates neuronal hyperexcitability in the hippocampus of PS19-fE4 mice. PS19-fE4: n = 20, N = 4; PS19-fE4/Syn1-Cre: n = 25, N = 4; PS19-fE3: n = 13, N = 2. Data are represented as mean ± s.e.m., one-way ANOVA with Tukey’s post hoc multiple comparisons test.Source data.
