Extended Data Fig. 6: PCA analyses of bulk cell RNA-Seq and scRNA-Seq data, and visualization of selected marker gene expression. | Nature Aging

Extended Data Fig. 6: PCA analyses of bulk cell RNA-Seq and scRNA-Seq data, and visualization of selected marker gene expression.

From: Insufficient epitope-specific T cell clones are responsible for impaired cellular immunity to inactivated SARS-CoV-2 vaccine in older adults

Extended Data Fig. 6

(a) PCA visualization of transcriptome profile from bulk cell RNA-Seq for CD4 T, CD8 T and B cells between young and old donors before and after vaccination. (b) PCA visualization of single-cell transcriptome profile for each sample of CD8 T cells specific to 7 distinct SARS-CoV-2 epitopes. The PCA plots showed no obvious batch effect among the analyzed scRNA-Seq datasets. (c) UMAP visualization of scRNA-Seq data with selected marker gene expression projection.

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