Fig. 2: Correlations of selected CSF p-tau concentrations and tau phosphorylation occupancies with amyloid PET Centiloid. | Nature Aging

Fig. 2: Correlations of selected CSF p-tau concentrations and tau phosphorylation occupancies with amyloid PET Centiloid.

From: CSF tau phosphorylation occupancies at T217 and T205 represent improved biomarkers of amyloid and tau pathology in Alzheimer’s disease

Fig. 2: Correlations of selected CSF p-tau concentrations and tau phosphorylation occupancies with amyloid PET Centiloid.The alternative text for this image may have been generated using AI.

a–j, CSF concentrations of p-tau217 (a), p-tau231 (c), p-tau181 (e), p-tau205 (g) and Aβ42 (i), and tau phosphorylation occupancies at T217 (b), T231 (d), T181 (f) and T205 (h), as well as Aβ42/Aβ40 (j), plotted as a function of amyloid PET Centiloid. Spearman’s correlations with 95% CIs are shown for the entire amyloid PET cohort (n = 750 individuals) and amyloid PET-positive individuals in the amyloid PET cohort (n = 263). The horizontal dashed lines denote the cut-offs that best distinguish amyloid PET status, based on combined sensitivity and specificity (Supplementary Table 3). The vertical dashed lines represent the cut-off for amyloid PET positivity. Each symbol represents one individual: blue circle: amyloid PET negative, CSF negative, CDR = 0; blue square: amyloid PET negative, CSF negative, CDR > 0; green circle: amyloid PET negative, CSF positive, CDR = 0; green square: amyloid PET negative, CSF positive, CDR > 0; green triangle: amyloid PET positive, CSF negative, CDR = 0; orange circle: amyloid PET positive, CSF positive, CDR = 0; red circle: amyloid PET positive, CSF positive, CDR = 0.5; and red square: amyloid PET positive, CSF positive, CDR > 0.5.

Back to article page