Extended Data Fig. 6: CISH-dependent amphisome-rich T cells from older individuals do not show evidence of apoptosis. | Nature Aging

Extended Data Fig. 6: CISH-dependent amphisome-rich T cells from older individuals do not show evidence of apoptosis.

From: CISH impairs lysosomal function in activated T cells resulting in mitochondrial DNA release and inflammaging

Extended Data Fig. 6

a, Naïve CD4+ T cells were transfected with control or indicated siRNA and activated for 3 days (n = 4). Cell apoptosis was examined by staining with Annexin V and 7-AAD. Statistical significance by two-tailed unpaired t-test. NS, not significant. b, Day3-stimulated naïve CD4+ T cells were left untreated or treated with 1 μM Staurosporine for 24 h. Scale bar, 1 μm. Cells were then processed for TEM. Data are presented as mean ± s.e.m.

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