Extended Data Fig. 2: Non-immune dermal cell populations during aging.
From: Targeting lymphoid-derived IL-17 signaling to delay skin aging
a, Violin plots showing expression of senescent-associated markers Cdkn1a (p21) and Cdkn2a (p16) in non-immune (CD45-/EpCAM-) cell populations. b, Violin plots showing average expression of the skin aging-associated secreted protein (SAASP) signature comparing adult and aged fibroblast populations(Waldera Lupa, Kalfalah et al. 2015). c, Box plots showing changes in proportion of non-immune (CD45-) cell populations in adult and aged conditions obtained with sccomp(Mangiola 2022) obtained with the scRNA-seq data. Error bars indicate the 95% credible intervals, center line is the median. The black boxplots represent the observed data, while blue ones indicate the posterior predictive check of the model. Boxes colored in orange indicate statistically significant differences in cell proportion between conditions (FDR < 0.025 using Benjamini-Hochberg procedure to control for multiple testing).
