Extended Data Fig. 7: Effect of ABT-263 treatment on lung pathology and body weight loss during a SARS-CoV-2 infection. | Nature Aging

Extended Data Fig. 7: Effect of ABT-263 treatment on lung pathology and body weight loss during a SARS-CoV-2 infection.

From: Removal of senescent cells reduces the viral load and attenuates pulmonary and systemic inflammation in SARS-CoV-2-infected, aged hamsters

Extended Data Fig. 7

Aged hamsters and young hamsters were treated (or not) with ABT-263 and then infected with SARS-CoV-2. A, Representative micrographs showing H&E-stained lungs from aged hamsters and young hamsters treated (or not) with ABT-263 (magnification: x 2.5). The percentage of lung sections affected by subacute bronchointerstitial pneumonia (consolidation) is depicted for each group of animals (lower panel, (n = 11-12 aged and n = 6 young). B, Body weight loss curves for infected animals (n = 5-6). C, Heatmaps of the differential expressed components in the lungs of vehicle-treated and ABT-263-treated aged hamsters, in a mass-spectrometry analysis of the proteome (fold change in protein abundance >2, P < 0.05) (n = 4). Pooled results from two independent experiments (A left, B and C) and one of two representative experiments (A right) are shown. For all graphs, errors indicate mean ± SD. A and C, Significant differences were determined using the two tailed Mann Whitney U test. ** P < 0.01.

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