Extended Data Fig. 2: Basic universal clock for log-transformed age.
From: Universal DNA methylation age across mammalian tissues
a, b, Chronological age (x-axis) versus DNAmAge estimated using a, leave-one-fraction-out (LOFO) and b, leave-one-species-out (LOSO) analysis. The gray and black dashed lines correspond to the diagonal line (y = x) and the regression line, respectively. Each sample is labeled by the mammalian species index (legend). The species index corresponds to the taxonomic order, for example 1 = primates, 2 = elephants (Proboscidea) etc. (legend). The numbers after the first and second decimal points enumerate the taxonomic family and species, respectively. Points are colored by tissue type (Supplementary Data 1.4). The heading of each panel reports the Pearson correlation (cor) across all samples. Here med.Cor denotes the median value across species that contain at least 15 samples. c–f, The y-axis reports the mean difference between the LOSO estimate of DNAm age and chronological age evaluated at a fixed age defined as half the maximum lifespan (denoted as Mean Delta.Age). The scatter plots depict mean delta half lifespan per species (y-axis) versus c, maximum lifespan observed in the species, d, average age at sexual maturity e, gestational time (in units of years), and f, (log-transformed) average adult body mass in units of grams. All P-values reported are unadjusted and are based on two-sided tests.
