Extended Data Fig. 8: Overlap with late-replicating domains.
From: Universal DNA methylation age across mammalian tissues
The heatmap color-codes the hypergeometric overlap analysis between age-related CpGs (columns) and CpGs related to late-replicating domains in hg19 and mm10 assembly50, respectively. Two groups of late-replicating domains were analyzed (1) common PMD/HMD structures: highly methylated domains (commonHMD), partially methylated domains (commonPMD), and neither (Neither), and (2) solo-WCGW structures: genome-wide (solo-WCGW) and those in the common PMD regions (solo-WCGW commonPMDs). The y-axis lists categories of late-replicating domains and number of mammalian array CpGs inside parentheses for Hg19 and mm10 genome, respectively. For each row, the table reports odds ratios (OR) from hypergeometric test results for the top 1,000 CpGs that increased/decreased with age from meta-EWAS of age across all, blood, skin, liver, muscle, brain, and cerebral cortex tissues, respectively. The heatmap color gradient is based on -log10 (unadjusted hypergeometric P value) multiplied by the sign of OR greater than one. Red colors denote OR greater than one in contrast with blue colors for OR less than one. The left/right panel lists the results based on the top 1,000 CpGs with positive/negative age correlation. Unadjusted P values are reported and derived from one-sided hypergeometric tests.
