Extended Data Fig. 6: Expression of inhibitory receptors markers and cytokines by virus-specific CD8 + T cells.
a, Expression of IFNγ (gp33 + : young ctrl vs old UA P-value = 0.0112; np396+: young ctrl vs old UA P-value = 0.0034; old ctrl vs old UA P-value = 0.0160), TNFα (gp33 + :young ctrl vs old ctrl P-value < 0.0001; young ctrl vs old UA P-value = 0.0003; np396+:young ctrl vs old ctrl P-value < 0.0001; young ctrl vs old UA P-value < 0.0001) and IL-2 by CD8+ T cells in response to restimulation with gp33 or np396 peptides. b, Expression of co- inhibitory receptors PD-1 (gp33 + :young ctrl vs old ctrl P-value < 0.0001; young ctrl vs old UA P-value = 0.0125; old ctrl vs old UA P-value = 0.0146 np396+:young ctrl vs old ctrl P-value < 0.0001; young ctrl vs old UA P-value = 0.0025; old ctrl vs old UA P-value = 0.0159)and Lag3 (gp33 + :young ctrl vs old ctrl P-value < 0.0001; young ctrl vs old UA P-value = 0.0007; old ctrl vs old UA P-value = 0.0173; np396+:young ctrl vs old ctrl P-value < 0.0001; young ctrl vs old UA P-value < 0.0001; old ctrl vs old UA P-value = 0.0301) by gp33+ and np396 CD44+ CD8+ T cells (n = 10; values are mean ± s.e.m.; two-way ANOVA; * P ≤ 0.05, ** P ≤ 0.01, *** P ≤ 0.001, **** P ≤ 0.0001).
