Extended Data Fig. 3: UA improves Colony forming capacity (CFU assay) of old human HSCs.
a, 1000 CD34+CD38−CD45RA- cells derived from the bone marrow of anonymous old adults (58-77 years old) were treated for 3 days with 20μM UA, and colony formations was measured at 15 days post seeding and replated for secondary CFUs. b, analysis of primary CFUs (P-value < 0.0001) (n = 14; values are mean ± s.e.m.; two-tailed Student’s t test; * P ≤ 0.05, ** P ≤ 0.01, *** P ≤ 0.001). c, Assessment of long-term hematopoietic capacity by secondary CFUs analysis (P-value = 0.0042) (n = 8; values are mean ± s.e.m.; two-tailed Student’s t test; * P ≤ 0.05, ** P ≤ 0.01, *** P ≤ 0.001).
