Extended Data Fig. 9: 3xDR does not increase anxiety level or social deficit.
From: Transcriptional and epigenetic decoding of the microglial aging process
(a) 3xDR does not influence the body weight of mice. N = 5 mice for each group. Multiple t test. (b) Open field test reveals that the total distance and time spent in the center zone were comparable among young (3-month-old), aged (21-month-old), control and 3xDR mice, indicating that 3xDR does not increase anxiety-like behavior. N = 12, 22, 11 and 11 for young, aged, control and 3xDR mice, respectively. One-way ANOVA. (c) Three-chamber test shows that sniff times in the sociability stage and social novelty stage are not changed in 3xDR mice, indicating that 3xDR does not exhibit the social deficit. N = 8 for control mice and 7 for 3xDR mice. Two-tailed independent t test. Data are presented as mean ± SD. Ctrl: control; 3xDR: 3-round depletion-repopulation.
