Fig. 8: scRNA-seq characterizes the microglial crosstalk with OPCs and OLs in control and 3xDR brains. | Nature Aging

Fig. 8: scRNA-seq characterizes the microglial crosstalk with OPCs and OLs in control and 3xDR brains.

From: Transcriptional and epigenetic decoding of the microglial aging process

Fig. 8: scRNA-seq characterizes the microglial crosstalk with OPCs and OLs in control and 3xDR brains.The alternative text for this image may have been generated using AI.

a, Scheme of the forced microglial turnover model and timepoints for experiments. Control mice are sex-matched and age-matched animals fed with CD for 130 d. b, tSNE plots of 11,952 control and 8,914 3xDR microglia, revealing an aged-like phenotype of 3xDR microglia. c, Dot plot showing the expression levels of well-known representative cell-type-enriched marker genes across all 16 cell types (18 populations). d, Significant ligand–receptor interactions predicted by CellPhoneDB. One-sided permutation test. e, Significant molecule–molecule interactions predicted by CellChat. One-sided permutation test. Hb-VC, hemoglobin-expressing vascular cell; ImmNeuron, immature neuron; mNeuron, mature neuron; NendC, neuroendocrine cell; OEG, olfactory ensheathing glia; VLMC, vascular and leptomeningeal cell; VSMC, vascular smooth muscle cell.

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