Extended Data Fig. 4: Alteration of the ability of tryptophan metabolism to produce IAA in APP/PS1 AD mice after oral administration l-Au NPs (n = 6).
From: Chiral nanoparticle-remodeled gut microbiota alleviates neurodegeneration via the gut–brain axis
(A) Schematic of the 13C10-IAA produced by 13C11- Trp in APP/PS1 AD mice experimental design. (B-C) Relative abundance of 13C10-IAA in APP/PS1 AD mice serum after oral administration of 13C11- Trp, or 13C11- Trp and l-Au NPs 8 h. i.g: Intragastric administration. Each ‘n’ represents an independent biological sample. One dot represents one mouse. Data are represented as the mean ± SD. ***p < 0.001. Two-tailed unpaired Student’s t-test.
