Extended Data Fig. 1: Pathologies of APP/PS1 AD mice through FMT (n = 6).
From: Chiral nanoparticle-remodeled gut microbiota alleviates neurodegeneration via the gut–brain axis
(A) Immunofluorescence of Aβ (red) and p-tau (green) in the hippocampus. (B) Representative immunostaining for Aβ (black arrows) and p-tau (black arrows) protein. (C) Nissl staining of neuro cells in the brains (hippocampus of mice with treatments for 60 days). l-Au→AD: fecal microbiota was transplanted from the donor mice, APP/PS1 AD mice orally administered l-Au NPs, into receptor APP/PS1 AD mice. HT of l-Au→AD: Heat-treatment (HT) of fecal microbiota from the donor mice, APP/PS1 AD mice orally administered l-Au NPs, were transplanted into receptor APP/PS1 AD mice. Scale bars, 50 μm. ‘AD’ stands for APP/PS1 AD model mice. Each ‘n’ represents an independent biological sample.
